Software Boosts Productivity for Batch and Lab Operations

stainless steel pharmaceutical factory equipment
Batch operations can benefit from SCADA
In the biotechnology sphere, repetitive batch operations are good candidates for the use of software to create a SCADA system providing not only control and data acquisition, but to serving as a database of recipes and production data from previous batches that can be compared and analyzed. Productivity can be enhanced by centralizing many functions, making them available to all connected operations.

ILS Automation has developed a software package, Batch Expert+, tailored for use with bioreactors. It also has capability to interface simultaneously with other lab instruments and equipment, providing a single location for all related data. The system is intended to boost productivity by centralizing the data acquisition and control operations, providing tools for trend analysis and other analytical functions.

The company lists some of the main features.
  • One application manages multiple brands/models of fermentors/bioreactors
  • Integrates multiple on-line and off-line field and lab instruments (mass-spec, cell density, external pumps, scales, gas flow controllers, etc.)
  • Common recipes
  • Recipe management
  • Remote monitoring and control
  • Intelligent alarming and alarm management
  • Data historian for process and assay data
  • Reporting and scheduling
  • Open SQL database is easily integrated with other business systems and applications, making Batch Expert+ architecture extensible and customizable
  • Freedom to experiment with new logic
  • Batch trend charting of live, historical, and assay data
  • Time or event-based control
  • 21 CFR Part 11 compliant
There is much more to be learned about how Batch Expert+ can improve performance. Share your batch operation challenges with a product specialist. Combining your process experience and knowledge with their product application expertise will produce the best solutions.



PID Controller Action Simply Explained

industrial process PID controller
PID Process Controller
Courtesy Precision Digital
In the industrial control sphere, PID stands for "proportional plus integral and derivative control", three actions used together in managing a control loop. Process loop controllers use one, two or all three of these to regulate a process by responding in a prescribed fashion to disturbances in the process variable. PID control is used in a wide variety of applications in industrial control and process system management.

Many types of PID controllers exist on the market and are used for controlling temperature, pressure, flow, and just about every other process variable. Here is a brief explanation of the three actions that make up the PID algorithm, without the math.
PID control algorithm diagram
PID Control Loop Diagram
Proportional Control Action (P): The controller output responds in proportion to an error signal. Think of error as simply the distance between where you are and where you want to be. A larger error value will generate a larger output response from the controller. When the process value (the measured value of what is being controlled) is close to the setpoint, output response is reduced.

Integral Control Action (I): The control system will increase the output if the error is present over a period of time. This is called integral control action. The integral portion of the algorithm helps drive the process value to the setpoint if the process reaches some equilibrium point that is not the setpoint. The purpose of integral action is to provide adequate control response to varying demands of the process. Integral action does not function independently, requiring the inclusion of proportional action too.

Derivative Control Action (D): To achieve a stable process, wide proportional band and low integral action are often needed. Due to these settings, the control system can exhibit too slow a response pattern. If large system disturbances occur over a wide range, additional elements are needed in the control algorithm to provide suitable response. Derivative control action, added to the effect of proportional and integral, provides response to not only the magnitude of deviation, but also the rate of change of the error.

Modern PID loop controllers are often provided with a function that will automatically select the proper constants for the PID parameters. What used to be a very time consuming and tedious job can now be done with the push of a button and allowing the controller to "learn" the process dynamics. PID controllers minimize error and optimize the accuracy of any process.

Share your control challenges and requirements with product specialists and combine your process knowledge with their product expertise to produce the most effective results.



Real Time Direct Process Monitoring With Optical Spectroscopy

optical spectroscopy unit for real time process measurement
Optical spectroscopy unit for real time process measurement
Courtesy Prozess Technologie
Measurement and monitoring of process conditions is an essential part of producing the desired output. Some operations require, or can benefit from, faster or more accurate measurement of process variables. This can be especially true for chemical processes that rely on accurate mixing of components.

Process analyzers are available in a wide variety of technologies, configurations, performance ranges, and price points. Selecting the best analyzer for a particular process, take into consideration these points.

  • Technology - Assess whether the technology is cabable of producing the results needed
  • Accuracy - Measurement at levels appropriate for the process and operating goals
  • Specificity - Ability to reliably measure the subject components
  • First cost
  • Continuing costs of maintenance, expendables, calibration
  • Ease of use and integration into overall process measurement and control scheme
  • Reliability
One manufacturer, Prozess Technologie, approaches process analysis with their Reveal optical spectroscopy analyzer. It is capable of operating continuously without ongoing operator interaction. Internal calibration software provides stability and reliability. The software suite for the instrument is compliant with numerous standards and a host of communication standards are supported to allow for easy integration into a process measurement and control system.

Pick up more detail about the Reveal unit below. Share your analytical process challenges with a product application specialist. Combining your process knowledge with their product expertise will produce effective solutions.



Measure Disinfectants, pH, Temperature, and ORP With One Instrument

water analyzer multi parameter pH, ORP,temperature,disinfectant
Krypton® Multi analyzer from Kuntze Instrument
Process control involves confirmation of the attainment of certain output conditions at various stages of the process or operation. This is necessary to assure that the input of the following step is at known conditions. These confirmation measurements can require substantial amounts of instrumentation, each with its own protocols, operating procedure, maintenance requirements, and other burdens of ownership and operation. Consolidating multiple measurement functions into a single instrument or unit of equipment can have advantages on many fronts.

The Kryton® Multi, from Kuntze Instruments, can measure up to five analytical parameters. The system includes analog inputs, PID control, analog outputs, relay outputs, alarms, automatic sensor cleaning, and a host of other useful features combined into a single compact unit. The system is provided complete with instrumentation, sensors, assembly and wiring. Common applications include monitoring of disinfection operations, process water, drinking water, and beverages. The Kryton®  is also available as a single parameter analyzer, designated model DES.

Share your liquid and process analytic challenges with a product specialist. Combining your process knowledge with their product application expertise will produce effective solutions.





Paths for Optimizing Chemical Industry Processes

Ingold pH probes for analytical processing
Ingold brand InPro pH probes
Courtesy Mettler Toledo
The success of an industrial process hinges upon simultaneously or continuously maintaining an array of variables within a comparatively narrow operating band. Operators rely heavily upon sensing and measuring equipment to provide critical information about process operation that cannot be gathered by the human senses.

There is a robust section of the measurement and control equipment industry devoted to analytical measurements for chemical processes. Mettler Toledo, with their Ingold brand of analytical instrumentation, has been a key player in the process analytical field for many years. Through continuous research and development, the company has innovated products that provide greater performance and operational benefits to their industrial process control customers.

The piece included below provides a useful overview of the company's analytical and measurement capabilities, with an emphasis on how the products are employed in various industries. Modern technology is incorporated to improve product life cycle performance and reduce maintenance burden.

See for yourself with a browse through the document included below. More information is available on products and applications from a specialist, with whom you should share your analytical process challenges. The most effective solutions will come from collaboration between process operators and analytical equipment specialists.



When Magnetic Level Indicators May Be Best Choice for Tank Liquid Level Measurement

magnetic level gauge configured for sanitary installation
Magnetic level gauge configured for sanitary installation
Courtesy Jogler
Fluid process control operations often involve vessel or tank storage of liquids. Continuous and accurate indication of the liquid level within the tank is an essential data point for process control decision making and safety. Several methods and instrument types are available for tank level measurement, each with its own set of attributes that may be advantageous for a particular installation. Selection criteria for a tank liquid level indicator may include:
  • Direct or indirect measurement of level
  • Level measurement accuracy and reliability
  • Tank shape, regular or irregular
  • Media compatibility with measurement device
  • Requirements for maintenance or calibration
  • Compatibility with process temperature and pressure range
  • Local display and visibility
  • Level indication signal type and transmission
  • Level alarm switches or other indicators
The selection of a magnetic level indicator, also referred to as a magnetic level gauge, for the project will likely be based upon at least one of the instrument's strengths. Magnetic level gauges have a host of potentially positive features for level indication.
  • Continuous level measurement
  • Operable without electric power
  • Direct visual tank fluid level indication, regardless of tank shape or profile.
  • Wide range of operating temperature and pressure
  • Breakage resistant construction
  • Range of construction materials available to accommodate corrosive media
  • Measuring indicators, switches, and transmitters mounted externally, without contacting the medium being measured.
  • Low maintenance operation.
  • Readable level indication from greater distance than glass sight gauges.
  • Applicable to large fluid level ranges with a single instrument.
Magnetic level indicators have a strong position in the tank liquid level measurement field and should be considered as a candidate for fulfilling those application requirements. There are many options available to customize the level indicator for each specific application. I have included a technical data sheet from Jogler, a manufacturer of level instrumentation, for more detail. Share your application challenges with a sales engineer that specializes in level measurement. Combining your process knowledge with their product application expertise will yield positive solutions.


Humidity and Temperature Transmitters for Demanding Humidity Measurement

Vaisala Humidity sensors and transmitters for process measurement and control
HMT330 Series Humidity and Temperature Transmitters
Courtesy Vaisala
Humidity, the amount of water vapor in the atmosphere or a gas, can be an important measurable attribute of an industrial process. Many are aware of the measurement of relative humidity in HVAC applications and its impact on human comfort in occupied spaces, but the measurement of water vapor in air can be a required measuring point in many other processes that pose far greater challenge.

In addition to common wall or duct mounting applications, where the instrument is easily inserted or placed into the environment to be measured, there are applications that call for special adaptations to the instrument or sensing probe.
  • High pressure
  • Vacuum
  • High temperature
  • High humidity
  • Pressurized pipelines
  • Presence of chemical contaminants
Meeting the full range of industrial process control operations requires stable measurements and the choice of multiple configurations and options to customize the instrument to the process demands. Here are some features worth considering.
  • Multiple variants to match the basic process requirement
  • Full 0 to 100% humidity measurement range up to +180°C (+356°F)
  • PT 100 RTD for accurate temperature measurement
  • Pressure tolerance up to 100 bar
  • Superior sensor accuracy and stability
  • Graphic display and keypad for local operation
  • Multilingual user interface
  • Good chemical tolerance
  • Corrosion resistant housing
  • Delivered with multi-point NIST traceable calibration certificate
  • Analog outputs, RS232/485, WLAN/LAN
  • MODBUS protocol support (RTU/TCP)
  • Long term manufacturer warranty
While not all processes may require, or benefit from, the inclusion of all the listed features and capabilities, reviewing what is available and considering which features may provide better operability in your process can be beneficial. I have included a data sheet below that illustrates the HMT330 Series of humidity and temperature transmitters from Vaisala. Share your humidity measurement challenges with a product specialist. Combining your process knowledge with their product application expertise will produce solid solutions.