Thursday, September 6, 2018

The Preparation of Pharmaceutical Waters

Pharmaceutical Waters
While the public considers municipal water to be “pure”, the pharmaceutical market considers municipal water (feedwater) just the starting point in producing pure water. Water is the most widely used excipient in pharmaceutical manufacturing, and pharmaceutical water is a multi-functional resource, crossing all disciplines in the pharmaceutical industry. Water is used as a raw material, solvent, ingredient, reagent, and clean-ing agent, and is produced in a variety of “pure” forms.

Purified Water (PW), Highly Purified Water (HPW), and Water for Injection (WFI) used in pharmaceutical processes are produced on site from the local potable water, which has been produced by the treatment of the feedwater.

This best practice guide, titled "Pharmaceutical Waters Guide for Regulatory Compliance, Analysis and Real-Time Release" and produced by Mettler Toledo Thornton, provides insight on the following topics:

DOWNLOAD THE FULL GUIDE HERE.

Pharma Waters Overview


  • The Preparation of Pharmaceutical Waters
  • Pharmacopeia Overview
  • Industry Trends for Pharmaceutical Waters

Process Analytical Technology (PAT) and Intelligent Sensor Management (ISM)


  • Ensuring Pharmaceutical Water Compliance in a PAT Environment

Total Organic Carbon


  • Total Organic Carbon Measurement is a Key Control Point for Pharmaceutical Water Systems
  • Improving Water System Performance Continuous Real-Time TOC Measurements
  • Case Study: Real-Time TOC Analysis Safeguards Water Purity
  • Case Study: In-line TOC Monitoring: Reduces Production Downtime
  • Case Study: Leading Water Treatment Solution Provider Chooses METTLER TOLEDO Thornton
  • The Value of Measuring TOC in CIP and Cleaning Validation Applications

Conductivity/Resistivity


  • Ensuring the Absence of Ionic Impurities with Conductivity/Resistivity Measurements
  • Calibration Solutions for Pharmaceutical Waters
  • Case Study: Clean in Place Systems Manufacturer Relies on METTLER TOLEDO

Ozone


  • Reliable, Cost-effective Sanitization the Power of Ozone
  • Application and Control of Ozone Sanitization for Pharmaceutical Waters
  • Case Study: Critical Ozone Measurement in Purified Water Systems