The Preparation of Pharmaceutical Waters

While the public considers municipal water to be “pure”, the pharmaceutical market considers municipal water (feedwater) just the starting point in producing pure water. Water is the most widely used excipient in pharmaceutical manufacturing, and pharmaceutical water is a multi-functional resource, crossing all disciplines in the pharmaceutical industry. Water is used as a raw material, solvent, ingredient, reagent, and clean-ing agent, and is produced in a variety of “pure” forms.

Purified Water (PW), Highly Purified Water (HPW), and Water for Injection (WFI) used in pharmaceutical processes are produced on site from the local potable water, which has been produced by the treatment of the feedwater.

This best practice guide, titled "Pharmaceutical Waters Guide for Regulatory Compliance, Analysis and Real-Time Release" and produced by Mettler Toledo Thornton, provides insight on the following topics:

DOWNLOAD THE FULL GUIDE HERE.

Pharma Waters Overview

• The Preparation of Pharmaceutical Waters
• Pharmacopeia Overview
• Industry Trends for Pharmaceutical Waters

Process Analytical Technology (PAT) and Intelligent Sensor Management (ISM)

• Ensuring Pharmaceutical Water Compliance in a PAT Environment

Total Organic Carbon

• Total Organic Carbon Measurement is a Key Control Point for Pharmaceutical Water Systems
• Improving Water System Performance Continuous Real-Time TOC Measurements
• Case Study: Real-Time TOC Analysis Safeguards Water Purity
• Case Study: In-line TOC Monitoring: Reduces Production Downtime
• Case Study: Leading Water Treatment Solution Provider Chooses METTLER TOLEDO Thornton
• The Value of Measuring TOC in CIP and Cleaning Validation Applications

Conductivity/Resistivity

• Ensuring the Absence of Ionic Impurities with Conductivity/Resistivity Measurements
• Calibration Solutions for Pharmaceutical Waters
• Case Study: Clean in Place Systems Manufacturer Relies on METTLER TOLEDO

Ozone

• Reliable, Cost-effective Sanitization the Power of Ozone
• Application and Control of Ozone Sanitization for Pharmaceutical Waters
• Case Study: Critical Ozone Measurement in Purified Water Systems

DOWNLOAD THE FULL GUIDE HERE.

Alliance Adds Thornton to Process Analytical Instrument Offering

Alliance Technical Sales, experienced provider of process analytical solutions throughout many industries, has added the Thornton brand of instruments to expand its offering of Mettler Toledo analytical products. Thornton specializes in on-line liquid process measurement solutions for pure and ultrapure water applications. The product line includes instrumentation and sensors providing high quality measurement of conductivity/resistivity, TOC, pH, ORP, dissolved oxygen, dissolved ozone, sodium, silica and bioburden. The Thornton line complements and expands the extent of Mettler Toledo products already available from Alliance Technical Sales.

Share your fluid process analytical challenges with product application experts, combining your process knowledge and experience with their product application expertise to develop effective solutions.

Process Analytics Product Catalog from Alliance Technical Sales, Inc.